Abstract
Intracerebroventricular administration of calcium severely depressed the locomotor activity of unanesthetized mice, producing ataxic gait and motor incoordination. Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium, suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.
Original language | English (US) |
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Pages (from-to) | 207-208 |
Number of pages | 2 |
Journal | Psychopharmacology |
Volume | 68 |
Issue number | 2 |
DOIs | |
State | Published - May 1980 |
Keywords
- Calcium
- Locomotor activity
- Pentobarbital
- Rolling roller performance
- Sleeping time
- Tolerance
ASJC Scopus subject areas
- Pharmacology