Effect of calcium on locomotor activity of mice

Yiu K. Fung, Norman J. Uretsky

Research output: Contribution to journalArticlepeer-review

Abstract

Intracerebroventricular administration of calcium severely depressed the locomotor activity of unanesthetized mice, producing ataxic gait and motor incoordination. Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium, suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.

Original languageEnglish (US)
Pages (from-to)207-208
Number of pages2
JournalPsychopharmacology
Volume68
Issue number2
DOIs
StatePublished - May 1980

Keywords

  • Calcium
  • Locomotor activity
  • Pentobarbital
  • Rolling roller performance
  • Sleeping time
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology

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