Effect of calcium on locomotor activity of mice

Yiu K. Fung; Norman J. Uretsky

doi:10.1007/BF00432143

Effect of calcium on locomotor activity of mice

Yiu K. Fung, Norman J. Uretsky

Oral Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Intracerebroventricular administration of calcium severely depressed the locomotor activity of unanesthetized mice, producing ataxic gait and motor incoordination. Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium, suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.

Original language	English (US)
Pages (from-to)	207-208
Number of pages	2
Journal	Psychopharmacology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1007/BF00432143
State	Published - May 1980

Keywords

Calcium
Locomotor activity
Pentobarbital
Rolling roller performance
Sleeping time
Tolerance

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00432143

Cite this

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abstract = "Intracerebroventricular administration of calcium severely depressed the locomotor activity of unanesthetized mice, producing ataxic gait and motor incoordination. Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium, suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.",

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AB - Intracerebroventricular administration of calcium severely depressed the locomotor activity of unanesthetized mice, producing ataxic gait and motor incoordination. Pretreatment with pentobarbital (30 mg/kg, IP) twice daily for 2 and 6 days partially reversed this effect of calcium, suggesting that calcium and pentobarbital may in part exert their depressant effect by a similar mechanism.

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KW - Locomotor activity

KW - Pentobarbital

KW - Rolling roller performance

KW - Sleeping time

KW - Tolerance

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Effect of calcium on locomotor activity of mice

Abstract

Keywords

ASJC Scopus subject areas

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