Effect of cell density on androgen regulation of the mRNA level of human prostatic acid phosphatase

Ming Fong Lin, Renee Garcia-Arenas

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The expression of human prostatic acid phosphatase (PAcP), a differentiation antigen of prostate epithelial cells, has been proposed to be regulated by androgen. We investigated this regulatory mechanism at the post-transcriptional level in LNCaP human prostate carcinoma cells, the only cultured cells that express PAcP. Our results demonstrated that the level of PAcP mRNA decreased when the cell density increased. Further, 5α-dihydrotestosterone, an active form of the endogenous androgen, stimulated the PAcP mRNA level in low-density cells; while, caused a decrease in high-density cells. Thus, in LNCaP human prostate carcinoma cells, cell density could modulate PAcP expression at the mRNA level including androgen regulation.

Original languageEnglish (US)
Pages (from-to)R21-R24
JournalMolecular and Cellular Endocrinology
Volume99
Issue number2
DOIs
StatePublished - Mar 1994

Keywords

  • Androgen regulation
  • Cell density
  • Prostatic acid phosphatase (Human)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Fingerprint Dive into the research topics of 'Effect of cell density on androgen regulation of the mRNA level of human prostatic acid phosphatase'. Together they form a unique fingerprint.

  • Cite this