Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice

Marilyn S. Petro; Irina V. Agarkova; Thomas M. Petro

doi:10.1016/j.jneuroim.2016.05.009

Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice

Marilyn S. Petro, Irina V. Agarkova, Thomas M. Petro

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Neuroinflammation induced during immune responses to viral infections in the brain affect behavior. Unexpected evidence that oral gavage of an algal virus in its host algal cells could alter cognition was further examined by directly injecting purified algal virus ATCV-1 intracranially into C57BL/6 mice. After 4 weeks, the ATCV-1 infection impaired delayed location recognition memory, and also reduced and anxiety. Corresponding to these effects, heightened ATCV-1, IL-6, iNOS, IFN-γ, and CD11b expression in brains was observed 3-days and/or 8-weeks post infection compared with control mice. These results imply that ATCV-1 infection damages the hippocampus via induction of inflammatory factors.

Original language	English (US)
Pages (from-to)	46-55
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	297
DOIs	https://doi.org/10.1016/j.jneuroim.2016.05.009
State	Published - Aug 15 2016

Keywords

Chlorella virus
Cognitive behavior
Cytokines
Neuroinflammation
Sociability
Spatial recognition

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2016.05.009

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title = "Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice",

abstract = "Neuroinflammation induced during immune responses to viral infections in the brain affect behavior. Unexpected evidence that oral gavage of an algal virus in its host algal cells could alter cognition was further examined by directly injecting purified algal virus ATCV-1 intracranially into C57BL/6 mice. After 4 weeks, the ATCV-1 infection impaired delayed location recognition memory, and also reduced and anxiety. Corresponding to these effects, heightened ATCV-1, IL-6, iNOS, IFN-γ, and CD11b expression in brains was observed 3-days and/or 8-weeks post infection compared with control mice. These results imply that ATCV-1 infection damages the hippocampus via induction of inflammatory factors.",

keywords = "Chlorella virus, Cognitive behavior, Cytokines, Neuroinflammation, Sociability, Spatial recognition",

author = "Petro, {Marilyn S.} and Agarkova, {Irina V.} and Petro, {Thomas M.}",

note = "Funding Information: The authors thank Drs. Jim Van Etten and David Dunigan for their useful insights into the preparation of this manuscript. In addition we thank Marian Schmid for the excellent animal care expertise. This work was supported by funding from the University of Nebraska Medical Center Dept. of Oral Biology and College of Dentistry (TMP), the Stanley Medical Research Institute , and the National Institute of Health grant P30RR031151 from the COBRE program of the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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doi = "10.1016/j.jneuroim.2016.05.009",

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AU - Petro, Marilyn S.

AU - Agarkova, Irina V.

AU - Petro, Thomas M.

N1 - Funding Information: The authors thank Drs. Jim Van Etten and David Dunigan for their useful insights into the preparation of this manuscript. In addition we thank Marian Schmid for the excellent animal care expertise. This work was supported by funding from the University of Nebraska Medical Center Dept. of Oral Biology and College of Dentistry (TMP), the Stanley Medical Research Institute , and the National Institute of Health grant P30RR031151 from the COBRE program of the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health. Publisher Copyright: © 2016 Elsevier B.V.

PY - 2016/8/15

Y1 - 2016/8/15

N2 - Neuroinflammation induced during immune responses to viral infections in the brain affect behavior. Unexpected evidence that oral gavage of an algal virus in its host algal cells could alter cognition was further examined by directly injecting purified algal virus ATCV-1 intracranially into C57BL/6 mice. After 4 weeks, the ATCV-1 infection impaired delayed location recognition memory, and also reduced and anxiety. Corresponding to these effects, heightened ATCV-1, IL-6, iNOS, IFN-γ, and CD11b expression in brains was observed 3-days and/or 8-weeks post infection compared with control mice. These results imply that ATCV-1 infection damages the hippocampus via induction of inflammatory factors.

AB - Neuroinflammation induced during immune responses to viral infections in the brain affect behavior. Unexpected evidence that oral gavage of an algal virus in its host algal cells could alter cognition was further examined by directly injecting purified algal virus ATCV-1 intracranially into C57BL/6 mice. After 4 weeks, the ATCV-1 infection impaired delayed location recognition memory, and also reduced and anxiety. Corresponding to these effects, heightened ATCV-1, IL-6, iNOS, IFN-γ, and CD11b expression in brains was observed 3-days and/or 8-weeks post infection compared with control mice. These results imply that ATCV-1 infection damages the hippocampus via induction of inflammatory factors.

KW - Chlorella virus

KW - Cognitive behavior

KW - Cytokines

KW - Neuroinflammation

KW - Sociability

KW - Spatial recognition

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Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice

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Keywords

ASJC Scopus subject areas

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