Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice

Marilyn S. Petro, Irina V. Agarkova, Thomas M. Petro

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Neuroinflammation induced during immune responses to viral infections in the brain affect behavior. Unexpected evidence that oral gavage of an algal virus in its host algal cells could alter cognition was further examined by directly injecting purified algal virus ATCV-1 intracranially into C57BL/6 mice. After 4 weeks, the ATCV-1 infection impaired delayed location recognition memory, and also reduced and anxiety. Corresponding to these effects, heightened ATCV-1, IL-6, iNOS, IFN-γ, and CD11b expression in brains was observed 3-days and/or 8-weeks post infection compared with control mice. These results imply that ATCV-1 infection damages the hippocampus via induction of inflammatory factors.

Original languageEnglish (US)
Pages (from-to)46-55
Number of pages10
JournalJournal of Neuroimmunology
StatePublished - Aug 15 2016


  • Chlorella virus
  • Cognitive behavior
  • Cytokines
  • Neuroinflammation
  • Sociability
  • Spatial recognition

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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