Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model

Parviz M. Pour, Terence Lawson, Scott Helgeson, Thorkatla Donnelly, Katherin Stepan

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44 Scopus citations

Abstract

To examine the effect of cholecystokinin (CCK) on pancreatic carcinogenicity in the hamster model, two sets of experiments were carried out. In one study, CCK (20 IDU/kg body wt) was given 3 h before, simultaneously with or 3 h after a single dose (20 mg/kg body wt) of N-nitrosobis(2-oxopropyl)amine (BOP). In another experiment, hamsters were treated similarly except that both CCK (20 IDU/kg body wt) and BOP (2.5 mg/kg body wt) were given weekly for 20 weeks. The results showed that CCK in the first experiment (single BOP dose) inhibited pancreatic cancer induction in a statistically significant fashion when given either 3 h prior to (P<0.05) or simultaneously with BOP (P<0.0005); however, CCK, when administered after BOP did not alter the cancer incidence as compared with hamsters treated with BOP alone. In the second experiment (chronic BOP treatment) the pattern and the incidence of pancreatic tumors were not affected by CCK.

Original languageEnglish (US)
Pages (from-to)597-601
Number of pages5
JournalCarcinogenesis
Volume9
Issue number4
DOIs
StatePublished - Apr 1988

ASJC Scopus subject areas

  • Cancer Research

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