Effect of cold storage on mechanical properties of aorta

Shijia Zhao, Shelby Kutty, John Lof, Linxia Gu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aortic allografts have been widely used in treatments of congenital heart diseases with satisfactory clinical outcomes. They were usually cryopreserved and stored for surgical use. The objective of this work was to investigate the effect of cold storage on mechanical properties of aorta, since the compliance mismatch was one important factor associated with the complication after graft surgery. The segments of porcine descending aorta were divided into two groups: The fresh samples which were tested within 24 hours after harvesting served as control group, and frozen samples which were stored in-20°C for 7 days and then thawed. The uniaxial tension tests along circumferential direction and indentation tests were conducted. The average incremental elastic moduli within each stretch range were obtained from the experimental data obtained during tension tests, and the elastic moduli were also calculated by fitting the force-indentation depth data to Hertz model when the tissue was stretched at 1.0, 1.2, 1.4 and 1.6. In addition, the average incremental elastic moduli of both fresh and frozen aortic tissue along axial direction were also obtained by using uniaxial tension tests. The comparison showed that cold storage definitely increased the average incremental elastic modulus of the aortic tissue along circumferential direction; however, the difference is not significant for the elastic moduli along axial direction.

Original languageEnglish (US)
Title of host publicationMechanics of Solids, Structures and Fluids
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791857526
DOIs
StatePublished - 2015
EventASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015 - Houston, United States
Duration: Nov 13 2015Nov 19 2015

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume9-2015

Other

OtherASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015
CountryUnited States
CityHouston
Period11/13/1511/19/15

ASJC Scopus subject areas

  • Mechanical Engineering

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    Zhao, S., Kutty, S., Lof, J., & Gu, L. (2015). Effect of cold storage on mechanical properties of aorta. In Mechanics of Solids, Structures and Fluids (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 9-2015). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2015-51610