TY - GEN
T1 - Effect of cold storage on mechanical properties of aorta
AU - Zhao, Shijia
AU - Kutty, Shelby
AU - Lof, John
AU - Gu, Linxia
N1 - Publisher Copyright:
Copyright © 2015 by ASME.
PY - 2015
Y1 - 2015
N2 - Aortic allografts have been widely used in treatments of congenital heart diseases with satisfactory clinical outcomes. They were usually cryopreserved and stored for surgical use. The objective of this work was to investigate the effect of cold storage on mechanical properties of aorta, since the compliance mismatch was one important factor associated with the complication after graft surgery. The segments of porcine descending aorta were divided into two groups: The fresh samples which were tested within 24 hours after harvesting served as control group, and frozen samples which were stored in-20°C for 7 days and then thawed. The uniaxial tension tests along circumferential direction and indentation tests were conducted. The average incremental elastic moduli within each stretch range were obtained from the experimental data obtained during tension tests, and the elastic moduli were also calculated by fitting the force-indentation depth data to Hertz model when the tissue was stretched at 1.0, 1.2, 1.4 and 1.6. In addition, the average incremental elastic moduli of both fresh and frozen aortic tissue along axial direction were also obtained by using uniaxial tension tests. The comparison showed that cold storage definitely increased the average incremental elastic modulus of the aortic tissue along circumferential direction; however, the difference is not significant for the elastic moduli along axial direction.
AB - Aortic allografts have been widely used in treatments of congenital heart diseases with satisfactory clinical outcomes. They were usually cryopreserved and stored for surgical use. The objective of this work was to investigate the effect of cold storage on mechanical properties of aorta, since the compliance mismatch was one important factor associated with the complication after graft surgery. The segments of porcine descending aorta were divided into two groups: The fresh samples which were tested within 24 hours after harvesting served as control group, and frozen samples which were stored in-20°C for 7 days and then thawed. The uniaxial tension tests along circumferential direction and indentation tests were conducted. The average incremental elastic moduli within each stretch range were obtained from the experimental data obtained during tension tests, and the elastic moduli were also calculated by fitting the force-indentation depth data to Hertz model when the tissue was stretched at 1.0, 1.2, 1.4 and 1.6. In addition, the average incremental elastic moduli of both fresh and frozen aortic tissue along axial direction were also obtained by using uniaxial tension tests. The comparison showed that cold storage definitely increased the average incremental elastic modulus of the aortic tissue along circumferential direction; however, the difference is not significant for the elastic moduli along axial direction.
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U2 - 10.1115/IMECE2015-51610
DO - 10.1115/IMECE2015-51610
M3 - Conference contribution
AN - SCOPUS:84981237539
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
BT - Mechanics of Solids, Structures and Fluids
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2015 International Mechanical Engineering Congress and Exposition, IMECE 2015
Y2 - 13 November 2015 through 19 November 2015
ER -