Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation

Gen’i Murasaki, Samuel M. Cohen

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The effect of sodium saccharin fed to male F344 rats at levels of 5.0, 2.5, 1.0, 0.5, and 0.1% of the diet for 10 weeks was evaluated by autoradiography and scanning electron mi croscopy. A dose response was evident with both techniques. The labeling index was statistically significantly elevated at all doses above 0.1%. As observed by scanning electron micros copy, the number of foci containing ropy microridges or uniform microvilli was elevated at doses of 1.0, 2.5, and 5.0% of the diet, and pleomorphic microvilli were observed at the two highest doses.

Original languageEnglish (US)
Pages (from-to)942-944
Number of pages3
JournalCancer Research
Volume41
Issue number3
StatePublished - Mar 1 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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