The effect of sodium saccharin fed to male F344 rats at levels of 5.0, 2.5, 1.0, 0.5, and 0.1% of the diet for 10 weeks was evaluated by autoradiography and scanning electron mi croscopy. A dose response was evident with both techniques. The labeling index was statistically significantly elevated at all doses above 0.1%. As observed by scanning electron micros copy, the number of foci containing ropy microridges or uniform microvilli was elevated at doses of 1.0, 2.5, and 5.0% of the diet, and pleomorphic microvilli were observed at the two highest doses.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Mar 1 1981|
ASJC Scopus subject areas
- Cancer Research