Effect of ethanol and its metabolites on microtubule formation

Richard B. Jennett; D. J. Tuma; Michael F. Sorrell

doi:10.1159/000137453

Effect of ethanol and its metabolites on microtubule formation

Richard B. Jennett, D. J. Tuma, Michael F. Sorrell

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41 Scopus citations

Abstract

Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

Original language	English (US)
Pages (from-to)	363-368
Number of pages	6
Journal	Pharmacology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1159/000137453
State	Published - 1980

Keywords

Acetaldehyde
Acetate
Ethanol
Microtubules
Tubulin polymerization

ASJC Scopus subject areas

Pharmacology

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title = "Effect of ethanol and its metabolites on microtubule formation",

abstract = "Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.",

keywords = "Acetaldehyde, Acetate, Ethanol, Microtubules, Tubulin polymerization",

author = "Jennett, {Richard B.} and Tuma, {D. J.} and Sorrell, {Michael F.}",

year = "1980",

doi = "10.1159/000137453",

language = "English (US)",

volume = "21",

pages = "363--368",

journal = "Pharmacology",

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T1 - Effect of ethanol and its metabolites on microtubule formation

AU - Jennett, Richard B.

AU - Tuma, D. J.

AU - Sorrell, Michael F.

PY - 1980

Y1 - 1980

N2 - Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

AB - Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

KW - Acetaldehyde

KW - Acetate

KW - Ethanol

KW - Microtubules

KW - Tubulin polymerization

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JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 5

ER -

Effect of ethanol and its metabolites on microtubule formation

Abstract

Keywords

ASJC Scopus subject areas

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