Effect of ethanol and its metabolites on microtubule formation

Richard B. Jennett, D. J. Tuma, Michael F. Sorrell

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalPharmacology
Volume21
Issue number5
DOIs
StatePublished - 1980

Keywords

  • Acetaldehyde
  • Acetate
  • Ethanol
  • Microtubules
  • Tubulin polymerization

ASJC Scopus subject areas

  • Pharmacology

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