Effect of Fatigue on Health-Related Quality of Life and Work Productivity in Psoriatic Arthritis: Findings From a Real-World Survey

Laure Gossec, Jessica A. Walsh, Kaleb Michaud, Elizabeth Holdsworth, Steve Peterson, Sophie Meakin, Feifei Yang, Nicola Booth, Soumya D. Chakravarty, James Piercy, Natalie Dennis, Alexis Ogdie

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective. To evaluate fatigue frequency and severity among patients with psoriatic arthritis (PsA) and assess the effect of fatigue severity on patient-reported outcome measures (PROMs) assessing quality of life, function, and work productivity. Methods. Data were derived from the Adelphi Disease Specific Programme, a cross-sectional survey conducted in 2018 in the United States and Europe. Patients had physician-confirmed PsA. Fatigue was collected as a binary variable and through its severity (0-10 scale, using the 12-item Psoriatic Arthritis Impact of Disease fatigue question) from patients; physicians also reported patient fatigue (yes/no). Other PROMs included the 5-level EuroQol 5-dimension questionnaire (EQ-5D-5L) for health-related quality of life (HRQOL), Health Assessment Questionnaire–Disability Index, and Work Productivity and Activity Impairment Questionnaire. Multivariate linear regression was used to evaluate the association between fatigue severity and other PROMs. Results. Among the 831 included patients (mean age 47.5 yrs, mean disease duration 5.3 yrs, 46.9% female, 48.1% receiving a biologic), fatigue was reported by 78.3% of patients. Patients with greater fatigue severity had greater disease duration, PsA severity, pain levels, body surface area affected by psoriasis, and swollen and tender joint counts (all P < 0.05). In multivariate analyses, patients with greater fatigue severity experienced worse physical functioning, HRQOL, and work productivity (all P < 0.001). Presence of fatigue was under-reported by physicians (reported in only 32% of patients who self-reported fatigue). Conclusion. Prevalence of patient-reported fatigue was high among patients with PsA and underrecognized by physicians. Fatigue severity was associated with altered physical functioning, work productivity, and HRQOL.

Original languageEnglish (US)
Pages (from-to)1221-1228
Number of pages8
JournalJournal of Rheumatology
Issue number11
StatePublished - Nov 1 2022


  • fatigue
  • health-related quality of life
  • patient-reported outcomes
  • psoriatic arthritis
  • real-world data
  • work productivity

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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