Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice

Stefano Tarantini, Andriy Yabluchanskiy, Merry L. Lindsey, Anna Csiszar, Zoltan Ungvari

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Clinical and experimental studies show that hypertension induces intracerebral hemorrhages (ICH), including cerebral microhemorrhages in the aged brain, which contribute to the pathogenesis of vascular cognitive impairment (VCI). Previous studies showed that aging increased oxidative stress-mediated activation of matrix metalloproteinases (MMPs) that importantly contributes to the pathogenesis of ICHs. In particular, oxidative stress has been implicated in activation of MMP-9, which is known to be involved in the degradation of the extracellular matrix and cleavage of collagen IV, a key constituent of the basal membrane of cerebral vessels. To determine the role of MMP-9 activation in the genesis of ICHs, we induced hypertension in 20-month-old MMP-9 null and age-matched control mice by angiotensin II and L-NAME treatment. Contrary to our hypothesis, MMP-9 deficiency did not delay the onset or incidence of neurological consequences of hypertension-induced ICHs. Our results indicate that MMP-9 activation does not play a role in the age-related exacerbation of hypertension-induced ICH.

Original languageEnglish (US)
Pages (from-to)2611-2619
Number of pages9
JournalGeroScience
Volume43
Issue number5
DOIs
StatePublished - Oct 2021

Keywords

  • Aging
  • Arteriole
  • Artery
  • Cerebral microhemorrhage
  • Microbleed
  • Oxidative stress
  • Stroke

ASJC Scopus subject areas

  • Aging
  • veterinary (miscalleneous)
  • Complementary and alternative medicine
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice'. Together they form a unique fingerprint.

Cite this