Effect of gentamicin treatment on adenylate cyclase and Na+,K+-ATPase activities in renal tissues of rats

S. F. Queener, F. C. Luft, F. G. Hamel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.

Original languageEnglish (US)
Pages (from-to)815-818
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number5
StatePublished - 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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