Effect of gentamicin treatment on adenylate cyclase and Na+,K+-ATPase activities in renal tissues of rats

S. F. Queener; F. C. Luft; F. G. Hamel

doi:10.1128/AAC.24.5.815

Effect of gentamicin treatment on adenylate cyclase and Na⁺,K⁺-ATPase activities in renal tissues of rats

S. F. Queener, F. C. Luft, F. G. Hamel

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Gentamicin (20 mg/kg) treatment of male rats reduced Na⁺,K⁺-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.

Original language	English (US)
Pages (from-to)	815-818
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	24
Issue number	5
DOIs	https://doi.org/10.1128/AAC.24.5.815
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.",

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AU - Luft, F. C.

AU - Hamel, F. G.

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AB - Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.

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Effect of gentamicin treatment on adenylate cyclase and Na⁺,K⁺-ATPase activities in renal tissues of rats

Abstract

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