Effect of grapefruit juice on blood cyclosporin concentration

G. C. Yee; D. L. Stanley; L. J. Pessa; T. D. Costa; S. E. Beltz; J. Ruiz; D. T. Lowenthal

doi:10.1016/S0140-6736(95)90700-9

Effect of grapefruit juice on blood cyclosporin concentration

G. C. Yee, D. L. Stanley, L. J. Pessa, T. D. Costa, S. E. Beltz, J. Ruiz, D. T. Lowenthal

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Abstract

Grapefruit juice increases blood concentrations of some dihydropyridine calcium-channel blockers, which are metabolised by the P450 enzymes that also metabolise cyclosporin. We evaluated, in a randomised cross-over study, the effect of grapefruit juice on blood cyclosporin concentrations in 14 healthy adults. Each subject was given oral cyclosporin 300 mg with 250 mL grapefruit juice, orange juice, or water. Area-under-the-curve (AUC) was significantly higher with grapefruit juice than with water or orange juice (means 7057, 4871, and 4932 ng h/mL, respectively; p<0·0001). Thus grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose.

Original language	English (US)
Pages (from-to)	955-956
Number of pages	2
Journal	The Lancet
Volume	345
Issue number	8955
DOIs	https://doi.org/10.1016/S0140-6736(95)90700-9
State	Published - Apr 15 1995
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/S0140-6736(95)90700-9

Cite this

@article{99fcd1c6c8ca4fd7a57f8f09ad7aee83,

title = "Effect of grapefruit juice on blood cyclosporin concentration",

abstract = "Grapefruit juice increases blood concentrations of some dihydropyridine calcium-channel blockers, which are metabolised by the P450 enzymes that also metabolise cyclosporin. We evaluated, in a randomised cross-over study, the effect of grapefruit juice on blood cyclosporin concentrations in 14 healthy adults. Each subject was given oral cyclosporin 300 mg with 250 mL grapefruit juice, orange juice, or water. Area-under-the-curve (AUC) was significantly higher with grapefruit juice than with water or orange juice (means 7057, 4871, and 4932 ng h/mL, respectively; p<0·0001). Thus grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose.",

author = "Yee, {G. C.} and Stanley, {D. L.} and Pessa, {L. J.} and Costa, {T. D.} and Beltz, {S. E.} and J. Ruiz and Lowenthal, {D. T.}",

note = "Funding Information: This study was funded by Hoffman-La Roche. Dr K Ariyoshi was Funding Information: supported by the UK Medical Research Council.",

year = "1995",

month = apr,

day = "15",

doi = "10.1016/S0140-6736(95)90700-9",

language = "English (US)",

volume = "345",

pages = "955--956",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "8955",

}

TY - JOUR

T1 - Effect of grapefruit juice on blood cyclosporin concentration

AU - Yee, G. C.

AU - Stanley, D. L.

AU - Pessa, L. J.

AU - Costa, T. D.

AU - Beltz, S. E.

AU - Ruiz, J.

AU - Lowenthal, D. T.

N1 - Funding Information: This study was funded by Hoffman-La Roche. Dr K Ariyoshi was Funding Information: supported by the UK Medical Research Council.

PY - 1995/4/15

Y1 - 1995/4/15

N2 - Grapefruit juice increases blood concentrations of some dihydropyridine calcium-channel blockers, which are metabolised by the P450 enzymes that also metabolise cyclosporin. We evaluated, in a randomised cross-over study, the effect of grapefruit juice on blood cyclosporin concentrations in 14 healthy adults. Each subject was given oral cyclosporin 300 mg with 250 mL grapefruit juice, orange juice, or water. Area-under-the-curve (AUC) was significantly higher with grapefruit juice than with water or orange juice (means 7057, 4871, and 4932 ng h/mL, respectively; p<0·0001). Thus grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose.

AB - Grapefruit juice increases blood concentrations of some dihydropyridine calcium-channel blockers, which are metabolised by the P450 enzymes that also metabolise cyclosporin. We evaluated, in a randomised cross-over study, the effect of grapefruit juice on blood cyclosporin concentrations in 14 healthy adults. Each subject was given oral cyclosporin 300 mg with 250 mL grapefruit juice, orange juice, or water. Area-under-the-curve (AUC) was significantly higher with grapefruit juice than with water or orange juice (means 7057, 4871, and 4932 ng h/mL, respectively; p<0·0001). Thus grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose.

UR - http://www.scopus.com/inward/record.url?scp=0028963036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028963036&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(95)90700-9

DO - 10.1016/S0140-6736(95)90700-9

M3 - Article

C2 - 7715295

AN - SCOPUS:0028963036

SN - 0140-6736

VL - 345

SP - 955

EP - 956

JO - The Lancet

JF - The Lancet

IS - 8955

ER -

Effect of grapefruit juice on blood cyclosporin concentration

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this