Effect of grapefruit juice on blood cyclosporin concentration

G. C. Yee, D. L. Stanley, L. J. Pessa, T. D. Costa, S. E. Beltz, J. Ruiz, D. T. Lowenthal

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

Grapefruit juice increases blood concentrations of some dihydropyridine calcium-channel blockers, which are metabolised by the P450 enzymes that also metabolise cyclosporin. We evaluated, in a randomised cross-over study, the effect of grapefruit juice on blood cyclosporin concentrations in 14 healthy adults. Each subject was given oral cyclosporin 300 mg with 250 mL grapefruit juice, orange juice, or water. Area-under-the-curve (AUC) was significantly higher with grapefruit juice than with water or orange juice (means 7057, 4871, and 4932 ng h/mL, respectively; p<0·0001). Thus grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose.

Original languageEnglish (US)
Pages (from-to)955-956
Number of pages2
JournalThe Lancet
Volume345
Issue number8955
DOIs
StatePublished - Apr 15 1995

ASJC Scopus subject areas

  • Medicine(all)

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