Effect of intracavitary probe size on the accuracy of inverse endocardial potential estimates

We simulated the effects of probe size on the accuracy of an intracavitary probe. Measured data was used to find the potentials over the entire endocardial surface. These "original" endocardial potentials were used with two models, one with a standard probe and the other with a probe half as large, to compute corresponding probe potentials. Random Gaussian noise was added to these "zero-noise" probe potentials. Using first-order Tikhonov regularization, the endocardial potentials for both models were estimated. Making the probe smaller had very little effect on the CC between the original endocardial signals and the estimated endocardial signals. These results suggest that even a probe half as large as that currently used clinically could be effectively used for patient treatment, so long as higher order regularization methods are employed.