Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 ± 0.8 to 7.1 to 7.1 ± 1.4 mm Hg (P < 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the other at 4 mm HJ. Four pairs of control eyes (without cyclodialysis) were perfused in the same manner. At 4 mm Hg, uveoscleral outflow was 0.02 ± 0.02 μl/min in control eyes and 0.05 ± 0.04 μl/min in eyes following cyclodialysis. However, at 35 mm Hg, uveoscleral outflow in eyes with cyclodialysis increased to 2.13 ± 0.47 μl/min compared to 0.32 ± 0.10 μl/min in control eyes. Thus the 'facility' of uveoscleral outflow in control eyes is 0.01 μl/min/mm Hg and in eyes following cyclodialysis is 0.07 μl/min/mm Hg. It is concluded that cyclodialysis results in a pressure-dependent increase in uveoscleral outflow.
|Original language||English (US)|
|Number of pages||5|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - 1985|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience