Effect of invariant chain on major histocompatibility complex class i molecule expression and stability on human breast tumor cell lines

Xuede Lin, Xiaojian Wang, Haley L. Capek, Laura C. Simone, Amit Tuli, Chantey R. Morris, Adrian J. Reber, Joyce C. Solheim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Invariant chain (Ii) binds to the human leukocyte antigen (HLA) class II molecule and assists it in the process of peptide acquisition. In addition, Ii binds to the HLA class I molecule, although there has been little study of its effects on the HLA class I molecule. In addition to its normal expression on antigen-presenting cells, Ii expression is up regulated in a variety of tumors. By flow cytometric analysis, we found that expression of Ii resulted in an increase in the number of cell surface HLA class I molecules and in the proportion of unstable HLA class I molecules at the surface of breast tumor cell lines. These data suggest that the expression of Ii by tumor cells may quantitatively and qualitatively alter the presentation of antigens on those cells.

Original languageEnglish (US)
Pages (from-to)729-736
Number of pages8
JournalCancer Immunology, Immunotherapy
Volume58
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • Antigen presentation
  • Antigens/peptides/epitopes
  • Breast cancer
  • Invariant chain
  • MHC class I molecule

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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