Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum

Othman Ghribi, Jacques Callebert, Michel Plotkine, Roger G. Boulu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We examined the effect of kynurenic acid, a broad spectrum antagonist of excitatory amino acid receptors, on striatal extracellular glutamate and aspartate accumulation induced by a 30 min forebrain ischaemia in rats. Kynurenic acid, given systemically (500 mg kg-1, i.p.) or administered in situ through the dialysis probe (10 mM), markedly depressed the ischaemia-induced increase in glutamate and aspartate concentrations. These results indicate that, during forebrain ischaemia, local glutamate receptors play a major role in glutamate and aspartate accumulation in the striatum. Ischaemia-induced increase in extracellular concentrations of these excitatory amino acids may be due in part to a positive glutamatergic feedback loop via activation of NMDA and/or non-NMDA receptors.

Original languageEnglish (US)
Pages (from-to)435-437
Number of pages3
JournalNeuroReport
Volume5
Issue number4
DOIs
StatePublished - Jan 1994

Keywords

  • Aspartate
  • Glutamate
  • Ischaemia
  • Kynurenic acid
  • Microdialysis
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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