Effect of N-cadherin misexpression by the mammary epithelium in mice

Karen A. Knudsen, Christa Sauer, Keith R. Johnson, Margaret J. Wheelock

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

N-cadherin is not typically expressed by epithelial cells. However, it is detected in breast cancers and increases tumor cell migration and invasion in vitro. To explore its misexpression, we generated transgenic mice with N-cadherin in the mammary epithelium. Mammary glands appeared normal and no tumors arose spontaneously. To investigate N-cadherin misexpression in mammary tumors, neu was overexpressed through breeding. Tumors developed in +/neu and N-cadherin/neu mice, although few tumors in bitransgenic mice expressed N-cadherin, and they did not differ from N-cadherin-negative tumors.

Original languageEnglish (US)
Pages (from-to)1093-1107
Number of pages15
JournalJournal of Cellular Biochemistry
Volume95
Issue number6
DOIs
StatePublished - Aug 15 2005

Keywords

  • Mammary gland
  • N-cadherin
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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