1. 1. The acute and chronic effects of nicotine (1.5 mg/kg/day) on the striatal and mesolimbic GABAergic systems were examined in the rat. 2. 2. Despite altering the striatal DAergic activity, neither acute nor chronic administration of nicotine significantly affected the GABAergic system. 3. 3. The nicotine treatment did not alter the ability of muscimol to inhibit the hyperactivity elicited by apomorphine. 4. 4. Similarly, the levels of GABA in striata and nucleus accumbens remained unchanged.
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