Effect of nicotine on central GABAergic system

Y. K. Fung; J. A. Reed

doi:10.1016/0306-3623(88)90159-0

Effect of nicotine on central GABAergic system

Y. K. Fung, J. A. Reed

Oral Biology

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Abstract

1. 1. The acute and chronic effects of nicotine (1.5 mg/kg/day) on the striatal and mesolimbic GABAergic systems were examined in the rat. 2. 2. Despite altering the striatal DAergic activity, neither acute nor chronic administration of nicotine significantly affected the GABAergic system. 3. 3. The nicotine treatment did not alter the ability of muscimol to inhibit the hyperactivity elicited by apomorphine. 4. 4. Similarly, the levels of GABA in striata and nucleus accumbens remained unchanged.

Original language	English (US)
Pages (from-to)	533-536
Number of pages	4
Journal	General Pharmacology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(88)90159-0
State	Published - 1988

ASJC Scopus subject areas

Pharmacology

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AB - 1. 1. The acute and chronic effects of nicotine (1.5 mg/kg/day) on the striatal and mesolimbic GABAergic systems were examined in the rat. 2. 2. Despite altering the striatal DAergic activity, neither acute nor chronic administration of nicotine significantly affected the GABAergic system. 3. 3. The nicotine treatment did not alter the ability of muscimol to inhibit the hyperactivity elicited by apomorphine. 4. 4. Similarly, the levels of GABA in striata and nucleus accumbens remained unchanged.

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Effect of nicotine on central GABAergic system

Abstract

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