Female mice between the ages of 1-18 months were treated with 50 mg oltipraz/kg by intragastric tube every other day for 5 doses. At all ages, oltipraz resulted in significant increases in hepatic glutathione content and glutathione reductase and glutathione S-transferase activities. Oltipraz also produced decreases in hepatic DNA damage (single strand breaks) and lipid peroxidation (malondialdehyde content). Highest hepatic glutathione content and glutathione reductase and glutathione S-transferase activities occurred in mice approximately 9 months of age, and declined thereafter. Oltipraz administration to 18 month old mice increased glutathione content and glutathione S-transferase activity approximately to the levels observed in 9 month old mice. Oltipraz may be effective in retarding the free radical reaction processes associated with aging and cancer.
ASJC Scopus subject areas
- Geriatrics and Gerontology