Effect of oltipraz on hepatic glutathione content and metabolism, DNA damage and lipid peroxidation in mice as a function of age

S. J. Stohs, T. Lawson, L. Anderson, E. Bueding

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Female mice between the ages of 1-18 months were treated with 50 mg oltipraz/kg by intragastric tube every other day for 5 doses. At all ages, oltipraz resulted in significant increases in hepatic glutathione content and glutathione reductase and glutathione S-transferase activities. Oltipraz also produced decreases in hepatic DNA damage (single strand breaks) and lipid peroxidation (malondialdehyde content). Highest hepatic glutathione content and glutathione reductase and glutathione S-transferase activities occurred in mice approximately 9 months of age, and declined thereafter. Oltipraz administration to 18 month old mice increased glutathione content and glutathione S-transferase activity approximately to the levels observed in 9 month old mice. Oltipraz may be effective in retarding the free radical reaction processes associated with aging and cancer.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalAGE
Volume9
Issue number3
DOIs
StatePublished - Jul 1986

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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