Effect of serotonin on blood flow to the choroid plexus

Frank M. Faraci; William G. Mayhan; Donald D. Heistad

doi:10.1016/0006-8993(89)91483-2

Effect of serotonin on blood flow to the choroid plexus

Frank M. Faraci, William G. Mayhan, Donald D. Heistad

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The choroid plexus contains a very high density of serotonin receptors and serotonin has been reported to influence the rate of formation of cerebrospinal fluid. The goal of this study was to examine effects of serotonin (5-hydroxytryptamine) on blood flow to the choroid plexus. Blood flow to the choroid plexus was measured in anesthetized cynomolgus monkeys and dogs using radioactive microspheres. Under control conditions, blood flow to choroid plexus was approximately 4 times greater than blood flow to the cerebrum in monkeys and approximately 7 times greater than blood flow to the cerebrum in dogs. Infusion of serotonin ( (40 μg·kg^-1·min^-1) into the left atrium increased blood flow to choroid plexus by 101±26% (mean ± S.E.M.) in monkeys and by 201 ± 45% in dogs. Serotonin did not affect cerebral blood flow. These findings suggest that serotonin may play an important role in regulation of blood flow to the choroid plexus.

Original language	English (US)
Pages (from-to)	121-126
Number of pages	6
Journal	Brain Research
Volume	478
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91483-2
State	Published - Jan 23 1989
Externally published	Yes

Keywords

5-Hydroxytryptamine
Adenosine
Cerebral circulation
Cynomolgus monkey
Dog
Microsphere

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91483-2

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title = "Effect of serotonin on blood flow to the choroid plexus",

abstract = "The choroid plexus contains a very high density of serotonin receptors and serotonin has been reported to influence the rate of formation of cerebrospinal fluid. The goal of this study was to examine effects of serotonin (5-hydroxytryptamine) on blood flow to the choroid plexus. Blood flow to the choroid plexus was measured in anesthetized cynomolgus monkeys and dogs using radioactive microspheres. Under control conditions, blood flow to choroid plexus was approximately 4 times greater than blood flow to the cerebrum in monkeys and approximately 7 times greater than blood flow to the cerebrum in dogs. Infusion of serotonin ( (40 μg·kg-1·min-1) into the left atrium increased blood flow to choroid plexus by 101±26% (mean ± S.E.M.) in monkeys and by 201 ± 45% in dogs. Serotonin did not affect cerebral blood flow. These findings suggest that serotonin may play an important role in regulation of blood flow to the choroid plexus.",

keywords = "5-Hydroxytryptamine, Adenosine, Cerebral circulation, Cynomolgus monkey, Dog, Microsphere",

author = "Faraci, {Frank M.} and Mayhan, {William G.} and Heistad, {Donald D.}",

note = "Funding Information: The authorst hankD rs. John Williamsa nd Steve Mooref or criticale valuatioonf this manuscripTt.h e technicaal ssistancoef Keith Breeseis gratefullya c-knowledgedS.u pportebdy MedicalI nvestigatorship and Researchfu ndsf romthe VeteransA dministra-tion, and by NationalI nstituteso f Health FIRST Award HL-38901,R CDA HL-02124P rogramP ro-ject Grants NS-24621a nd HL-14388, Research GrantsH L-16066a nd HL-40781,a nd ASCOR HL-14230.",

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N2 - The choroid plexus contains a very high density of serotonin receptors and serotonin has been reported to influence the rate of formation of cerebrospinal fluid. The goal of this study was to examine effects of serotonin (5-hydroxytryptamine) on blood flow to the choroid plexus. Blood flow to the choroid plexus was measured in anesthetized cynomolgus monkeys and dogs using radioactive microspheres. Under control conditions, blood flow to choroid plexus was approximately 4 times greater than blood flow to the cerebrum in monkeys and approximately 7 times greater than blood flow to the cerebrum in dogs. Infusion of serotonin ( (40 μg·kg-1·min-1) into the left atrium increased blood flow to choroid plexus by 101±26% (mean ± S.E.M.) in monkeys and by 201 ± 45% in dogs. Serotonin did not affect cerebral blood flow. These findings suggest that serotonin may play an important role in regulation of blood flow to the choroid plexus.

AB - The choroid plexus contains a very high density of serotonin receptors and serotonin has been reported to influence the rate of formation of cerebrospinal fluid. The goal of this study was to examine effects of serotonin (5-hydroxytryptamine) on blood flow to the choroid plexus. Blood flow to the choroid plexus was measured in anesthetized cynomolgus monkeys and dogs using radioactive microspheres. Under control conditions, blood flow to choroid plexus was approximately 4 times greater than blood flow to the cerebrum in monkeys and approximately 7 times greater than blood flow to the cerebrum in dogs. Infusion of serotonin ( (40 μg·kg-1·min-1) into the left atrium increased blood flow to choroid plexus by 101±26% (mean ± S.E.M.) in monkeys and by 201 ± 45% in dogs. Serotonin did not affect cerebral blood flow. These findings suggest that serotonin may play an important role in regulation of blood flow to the choroid plexus.

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Effect of serotonin on blood flow to the choroid plexus

Abstract

Keywords

ASJC Scopus subject areas

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