TY - JOUR
T1 - Effect of single intravenous doses of histamine2-receptor antagonists on volume and pH of gastric acid secretions in critically ill patients
AU - Olsen, Keith M.
AU - Hiller, F. Charles
AU - Ackerman, Bruce H.
AU - Crisp-Landwehr, Kelly
AU - San Pedro, Gerardo S.
N1 - Funding Information:
The authors thank the medical and surgery intensive care unit nursing staff for their assistance and cooperation. The study was performed at the University of Arkansas for Medical Sciences, Little Rock, Arkansas, and was supported in part by an unrestricted educational grant from Merck & Co., Inc., West Point, Pennsylvania.
PY - 1995/8
Y1 - 1995/8
N2 - The effects of single doses of cimetidine, famotidine, and ranitidine on gastric acid and fluid secretions in 12 critically ill, mechanically ventilated patients were evaluated in a prospective, randomized, crossover, single-blind trial. Each patient received an intravenous dose of cimetidine 300 mg, famotidine 20 mg, or ranitidine 50 mg diluted in 50 mL of normal saline and infused over 30 minutes. Each agent was administered in crossover fashion on consecutive days after the pH returned to baseline. Analysis of gastric fluids and pH measurements were determined from gastric samples collected every 15 minutes. Cimetidine, famotidine, and ranitidine treatment resulted in significant increases in gastric pH and decreased fluid production and total aspirated fluid volume. Famotidine maintained a gastric pH ≥4.0 for a mean duration of 16.5 ± 4.1 hours, significantly longer (P < 0.01) than cimetidine (2.3 ± 1.3 hours) or ranitidine (4.9 ± 0.8 hours). The percent of pH readings ≥4.0 was significantly (P < 0.01) greater for famotidine (88.0%) compared with cimetidine (38.5%) and ranitidine (55.6%). In critically ill patients given a single intravenous dose, famotidine suppressed acid secretion to a greater degree and for longer time periods than with either cimetidine or ranitidine.
AB - The effects of single doses of cimetidine, famotidine, and ranitidine on gastric acid and fluid secretions in 12 critically ill, mechanically ventilated patients were evaluated in a prospective, randomized, crossover, single-blind trial. Each patient received an intravenous dose of cimetidine 300 mg, famotidine 20 mg, or ranitidine 50 mg diluted in 50 mL of normal saline and infused over 30 minutes. Each agent was administered in crossover fashion on consecutive days after the pH returned to baseline. Analysis of gastric fluids and pH measurements were determined from gastric samples collected every 15 minutes. Cimetidine, famotidine, and ranitidine treatment resulted in significant increases in gastric pH and decreased fluid production and total aspirated fluid volume. Famotidine maintained a gastric pH ≥4.0 for a mean duration of 16.5 ± 4.1 hours, significantly longer (P < 0.01) than cimetidine (2.3 ± 1.3 hours) or ranitidine (4.9 ± 0.8 hours). The percent of pH readings ≥4.0 was significantly (P < 0.01) greater for famotidine (88.0%) compared with cimetidine (38.5%) and ranitidine (55.6%). In critically ill patients given a single intravenous dose, famotidine suppressed acid secretion to a greater degree and for longer time periods than with either cimetidine or ranitidine.
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U2 - 10.1016/0011-393X(95)85059-7
DO - 10.1016/0011-393X(95)85059-7
M3 - Article
AN - SCOPUS:0029080084
SN - 0011-393X
VL - 56
SP - 756
EP - 768
JO - Current Therapeutic Research
JF - Current Therapeutic Research
IS - 8
ER -