Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts

Debra L. Sudan, Stanley J. Radio, Aurelio Matamoros, Noel D. Johnson, C. Carson Shearon, Kimberly R. Glogowski, Arthur C. Hill, Timothy C. Goertzen, Ira J. Fox, Alan N. Langnas, William E. Beschorner

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6 Scopus citations

Abstract

Background. Organ xenografts are fulminantly rejected by antibody- mediated vascular rejection. Surrogate tolerogenesis (ST), the induction of tolerance within the donor, is effective with aorta xenografts. This preliminary study assesses the effect of ST on preformed antibodies and rejection of porcine heart xenografts. Methods. Tolerance to the donor pig was induced by infusing recipient marrow into fetal pigs. Later, pig splenocytes were transfused and heterotopic pig hearts transplanted using chimeric or nonchimeric pigs. Anti-pig antibodies were assessed. Results. With ST alone, xenografts developed cellular rejection at 4-6 days, whereas control grafts developed vascular rejection at 3-4 days (cellular vs. vascular, P<0.03). There was a reduction in preformed antibodies (P<0.03). ST combined with moderate cyclosporine prevented rejection at 9+ and 25 days in sensitized recipients compared with vascular rejection at 0.5-2 days for controls (P<0.07). Conclusions. ST seems to provide protection against vascular rejection. The cellular rejection seems sensitive to cyclosporine.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalTransplantation
Volume69
Issue number2
DOIs
StatePublished - Jan 27 2000

ASJC Scopus subject areas

  • Transplantation

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    Sudan, D. L., Radio, S. J., Matamoros, A., Johnson, N. D., Shearon, C. C., Glogowski, K. R., Hill, A. C., Goertzen, T. C., Fox, I. J., Langnas, A. N., & Beschorner, W. E. (2000). Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts. Transplantation, 69(2), 232-235. https://doi.org/10.1097/00007890-200001270-00007