Effect of terfenadine on cold air-induced bronchospasm

A. K. Bewtra, R. J. Hopp, N. M. Nair, R. G. Townley

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Cold air hyperventilation challenge (CAHC) has been shown to induce bronchoconstriction in asthmatics. We investigated whether terfenadine, a non-sedating H1 antihistamine, had a protective effect against CAHC. Twelve mild-moderate asthmatics, sensitive to both methacholine and CAHC, underwent a double-blind 3-way crossover study of terfenadine at doses of 0, 120, and 240 mg. For four hours after administration of the study drug, pulmonary responses were measured, followed by a CAHC. There was a significant improvement in pulmonary function on the 120-mg and 240-mg days. The percent drop in FEV1 to CAHC was determined by comparing the pre-challenge baseline to the challenge responses. There was a significant attenuation in the FEV1 fall immediately after challenge on active drug days, but it was not sustained. Terfenadine appears to have an attenuating effect against CAHC-induced bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)299-301
Number of pages3
JournalAnnals of Allergy
Volume62
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy

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