Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease

Madeleine Duvic; Alfred D. Steinberg; Lynell W. Klassen

doi:10.1002/art.1780210403

Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease

Madeleine Duvic, Alfred D. Steinberg, Lynell W. Klassen

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Treatment of female NZB/W F₁ mice with Nafoxidine, an anti‐estrogen, led to delayed manifestation of autoimmune features. Such treated mice had reduced anti‐DNA antibodies, reduced proteinuria, and improved survival. These results support the hypothesis that sex hormones play an important role in the expression of autoimmunity and suggest that estrogens may accelerate autoimmunity in NZB/W F₁ mice.

Original language	English (US)
Pages (from-to)	414-417
Number of pages	4
Journal	Arthritis & Rheumatism
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/art.1780210403
State	Published - May 1978
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780210403

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abstract = "Treatment of female NZB/W F1 mice with Nafoxidine, an anti‐estrogen, led to delayed manifestation of autoimmune features. Such treated mice had reduced anti‐DNA antibodies, reduced proteinuria, and improved survival. These results support the hypothesis that sex hormones play an important role in the expression of autoimmunity and suggest that estrogens may accelerate autoimmunity in NZB/W F1 mice.",

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Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease

Abstract

ASJC Scopus subject areas

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