Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease

Madeleine Duvic, Alfred D. Steinberg, Lynell W. Klassen

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Treatment of female NZB/W F1 mice with Nafoxidine, an anti‐estrogen, led to delayed manifestation of autoimmune features. Such treated mice had reduced anti‐DNA antibodies, reduced proteinuria, and improved survival. These results support the hypothesis that sex hormones play an important role in the expression of autoimmunity and suggest that estrogens may accelerate autoimmunity in NZB/W F1 mice.

Original languageEnglish (US)
Pages (from-to)414-417
Number of pages4
JournalArthritis & Rheumatism
Issue number4
StatePublished - May 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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