Effect of TNF priming of murine peritoneal macrophages on their activation to a tumoricidal state

Rakesh Kumar Singh; Ajit Sodhi

doi:10.1016/0165-2478(91)90110-V

Effect of TNF priming of murine peritoneal macrophages on their activation to a tumoricidal state

Rakesh Kumar Singh, Ajit Sodhi

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Murine peritoneal macrophages, on treatment with TNF (10 U/ml) for various durations, showed enhanced cytotoxicity against tumor target cells. The macrophage-mediated cytotoxicity was significantly enhanced when TNF-primed macrophages were treated with cisplatin, LPS, FK-565 or interferon-gamma for 24 h, compared to unprimed and treated macrophages. TNF-primed macrophages also showed enhanced expression of interleukin-1 and tumor necrosis factor activities on activation with different biological response modifiers.

Original language	English (US)
Pages (from-to)	127-133
Number of pages	7
Journal	Immunology Letters
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/0165-2478(91)90110-V
State	Published - May 1991
Externally published	Yes

Keywords

Activation
Cisplatin
FK-565
IL-1
Interferon-γ
Lipopolysaccharide
Macrophage
TNF priming

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0165-2478(91)90110-V

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title = "Effect of TNF priming of murine peritoneal macrophages on their activation to a tumoricidal state",

abstract = "Murine peritoneal macrophages, on treatment with TNF (10 U/ml) for various durations, showed enhanced cytotoxicity against tumor target cells. The macrophage-mediated cytotoxicity was significantly enhanced when TNF-primed macrophages were treated with cisplatin, LPS, FK-565 or interferon-gamma for 24 h, compared to unprimed and treated macrophages. TNF-primed macrophages also showed enhanced expression of interleukin-1 and tumor necrosis factor activities on activation with different biological response modifiers.",

keywords = "Activation, Cisplatin, FK-565, IL-1, Interferon-γ, Lipopolysaccharide, Macrophage, TNF priming",

author = "Singh, {Rakesh Kumar} and Ajit Sodhi",

note = "Funding Information: This work was supported by grants from CSIR-New Delhi. Rakesh Kumar Singh is a CSIR-Senior Research Fellow.",

year = "1991",

month = may,

doi = "10.1016/0165-2478(91)90110-V",

language = "English (US)",

volume = "28",

pages = "127--133",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Effect of TNF priming of murine peritoneal macrophages on their activation to a tumoricidal state

AU - Singh, Rakesh Kumar

AU - Sodhi, Ajit

N1 - Funding Information: This work was supported by grants from CSIR-New Delhi. Rakesh Kumar Singh is a CSIR-Senior Research Fellow.

PY - 1991/5

Y1 - 1991/5

N2 - Murine peritoneal macrophages, on treatment with TNF (10 U/ml) for various durations, showed enhanced cytotoxicity against tumor target cells. The macrophage-mediated cytotoxicity was significantly enhanced when TNF-primed macrophages were treated with cisplatin, LPS, FK-565 or interferon-gamma for 24 h, compared to unprimed and treated macrophages. TNF-primed macrophages also showed enhanced expression of interleukin-1 and tumor necrosis factor activities on activation with different biological response modifiers.

AB - Murine peritoneal macrophages, on treatment with TNF (10 U/ml) for various durations, showed enhanced cytotoxicity against tumor target cells. The macrophage-mediated cytotoxicity was significantly enhanced when TNF-primed macrophages were treated with cisplatin, LPS, FK-565 or interferon-gamma for 24 h, compared to unprimed and treated macrophages. TNF-primed macrophages also showed enhanced expression of interleukin-1 and tumor necrosis factor activities on activation with different biological response modifiers.

KW - Activation

KW - Cisplatin

KW - FK-565

KW - IL-1

KW - Interferon-γ

KW - Lipopolysaccharide

KW - Macrophage

KW - TNF priming

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U2 - 10.1016/0165-2478(91)90110-V

DO - 10.1016/0165-2478(91)90110-V

M3 - Article

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AN - SCOPUS:0025891003

SN - 0165-2478

VL - 28

SP - 127

EP - 133

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Effect of TNF priming of murine peritoneal macrophages on their activation to a tumoricidal state

Abstract

Keywords

ASJC Scopus subject areas

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