Effect of TNF priming of murine peritoneal macrophages on their activation to a tumoricidal state

Rakesh Kumar Singh, Ajit Sodhi

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Murine peritoneal macrophages, on treatment with TNF (10 U/ml) for various durations, showed enhanced cytotoxicity against tumor target cells. The macrophage-mediated cytotoxicity was significantly enhanced when TNF-primed macrophages were treated with cisplatin, LPS, FK-565 or interferon-gamma for 24 h, compared to unprimed and treated macrophages. TNF-primed macrophages also showed enhanced expression of interleukin-1 and tumor necrosis factor activities on activation with different biological response modifiers.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalImmunology Letters
Volume28
Issue number2
DOIs
StatePublished - May 1991
Externally publishedYes

Keywords

  • Activation
  • Cisplatin
  • FK-565
  • IL-1
  • Interferon-γ
  • Lipopolysaccharide
  • Macrophage
  • TNF priming

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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