Effects of 2, 4, 5-trichlorophenoxyacetic acid, pentachlorophenol, methylprednisolone, and freund’s adjuvant on 2-hydroxyethylnitrosourea carcinogenesis in mrc-wistar rats

S. S. Mirvish, J. Nickols, D. D. Weisenburger, D. Johnson, S. S. Joshi, P. Kaplan, M. Gross, H. Y. Tong

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A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98% pure 245T (600 mg/kg diet), 86% pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)59-74
Number of pages16
JournalJournal of Toxicology and Environmental Health
Issue number1
StatePublished - Jan 1991


ASJC Scopus subject areas

  • Toxicology
  • Pollution

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