TY - JOUR
T1 - Effects of 2, 4, 5-trichlorophenoxyacetic acid, pentachlorophenol, methylprednisolone, and freund’s adjuvant on 2-hydroxyethylnitrosourea carcinogenesis in mrc-wistar rats
AU - Mirvish, S. S.
AU - Nickols, J.
AU - Weisenburger, D. D.
AU - Johnson, D.
AU - Joshi, S. S.
AU - Kaplan, P.
AU - Gross, M.
AU - Tong, H. Y.
PY - 1991/1
Y1 - 1991/1
N2 - A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98% pure 245T (600 mg/kg diet), 86% pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.
AB - A link was proposed between human non-Hodgkin’s lymphoma and exposure to 2, 4, 5-trichlorophenoxyacetic acid (245T) and pentachlorophenol (PCP). To test this view and the hypothesis that immune suppression or stimulation could affect B-cell lymphoma (BCL) induction, we administered chronically to MRC-Wistar (MRC-W) rats of both sexes 98% pure 245T (600 mg/kg diet), 86% pure PCP (500 mg/kg diet), methyl- prednisolone (20 mg/kg ip weekly), and Freund’s adjuvant (0.5 ml im every 3-6 wk) for 40 wk, together with 75 mg 2-hydroxyethylnitrosourea (HENU)/I drinking water, a system known to induce B-cell lymphoma.
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U2 - 10.1080/15287399109531465
DO - 10.1080/15287399109531465
M3 - Article
C2 - 1987363
AN - SCOPUS:0025980943
SN - 0098-4108
VL - 32
SP - 59
EP - 74
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
IS - 1
ER -