Effects of a digital diabetes prevention program on cardiovascular risk among individuals with prediabetes

Tzeyu L. Michaud, Fabio A. Almeida, Gwenndolyn C. Porter, Carol A. Kittel, Robert J. Schwab, Fabiana A. Brito, Kathryn E. Wilson, Jeffrey A. Katula, Cynthia Castro Sweet, Paul A Estabrooks, Emily V. Dressler

Research output: Contribution to journalArticlepeer-review


Objective: To examine changes in cardiovascular disease (CVD) risk outcomes of overweight/obese adults with prediabetes. Methods: Using data from a randomized control trial of digital diabetes prevention program (d-DPP) with 599 participants. We applied the atherosclerotic CVD (ASCVD) risk calculator to predict 10-year CVD risk for d-DPP and small education (comparison) groups. Between-group risk changes at 4 and 12 months were compared using a repeated measures linear mixed-effect model. We examined within-group differences in proportion of participants over time for specific CVD risk factors using generalized estimating equations. Results: We found no differences between baseline 10-year ASCVD risk. Relative to the comparison group, the d-DPP group experienced greater reductions in predicted 10-year ASCVD risk at each follow-up visit and a significant group difference at 4 months (−0.96%; 95% confidence interval: −1.58%, −0.34%) (but not at 12 months). Additionally, we observed that the d-DPP group experienced a decreased proportion of individuals with hyperlipidemia (18% and 16% from baseline to 4 and 12 months), high-risk total cholesterol (8% from baseline to 12 months), and being insufficiently active (26% and 22% from baseline to 4 and 12 months at follow-up time points. Conclusions: Our findings suggest that a digitally adapted DPP may promote the prevention of cardiometabolic disease among overweight/obese individuals with prediabetes. However, given the lack of maintenance of effect on ASCVD risk at 12 months, there may also be a need for additional interventions to sustain the effect detected at 4 months.

Original languageEnglish (US)
Pages (from-to)148-154
Number of pages7
JournalPrimary Care Diabetes
Issue number2
StatePublished - Apr 2023


  • Cardiovascular risk factor
  • Chronic disease prevention
  • Digital health
  • Lifestyle intervention
  • Prediabetes

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Effects of a digital diabetes prevention program on cardiovascular risk among individuals with prediabetes'. Together they form a unique fingerprint.

Cite this