Effects of a hyperbaric environment on respiratory and monoamine oxidase activities

J. D. Geiger; S. J. Brumleve; J. N. Boelkins; S. S. Parmar

Effects of a hyperbaric environment on respiratory and monoamine oxidase activities

J. D. Geiger, S. J. Brumleve, J. N. Boelkins, S. S. Parmar

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Abstract

The effects of a prolonged hyperbaric environment (21 ATA He O₂, 200 ± 30 mm Hg O₂, 32.5 ± 1°C) were investigated on the respiratory activity of rat liver homogenates and the activity of monoamine oxidase in isolated rat liver preparations. Exposure to a hyperbaric environment for 84 days caused selective in vitro inhibition of nicotinamide adenine dinucleotide (NAD) dependent oxidation of pyruvate, D isocitrate, and α ketoglutarate by rat liver homogenates. The addition of NAD to the reaction mixture decreased the degree of such an inhibition. No effects on the in vitro activity of liver monoamine oxidase and its inhibition by pheniprazine were observed during exposure of animals to a prolonged high pressure environment.

Original language	English (US)
Pages (from-to)	131-137
Number of pages	7
Journal	Undersea Biomedical Research
Volume	3
Issue number	2
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Cite this

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abstract = "The effects of a prolonged hyperbaric environment (21 ATA He O2, 200 ± 30 mm Hg O2, 32.5 ± 1°C) were investigated on the respiratory activity of rat liver homogenates and the activity of monoamine oxidase in isolated rat liver preparations. Exposure to a hyperbaric environment for 84 days caused selective in vitro inhibition of nicotinamide adenine dinucleotide (NAD) dependent oxidation of pyruvate, D isocitrate, and α ketoglutarate by rat liver homogenates. The addition of NAD to the reaction mixture decreased the degree of such an inhibition. No effects on the in vitro activity of liver monoamine oxidase and its inhibition by pheniprazine were observed during exposure of animals to a prolonged high pressure environment.",

author = "Geiger, {J. D.} and Brumleve, {S. J.} and Boelkins, {J. N.} and Parmar, {S. S.}",

year = "1976",

language = "English (US)",

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T1 - Effects of a hyperbaric environment on respiratory and monoamine oxidase activities

AU - Geiger, J. D.

AU - Brumleve, S. J.

AU - Boelkins, J. N.

AU - Parmar, S. S.

PY - 1976

Y1 - 1976

N2 - The effects of a prolonged hyperbaric environment (21 ATA He O2, 200 ± 30 mm Hg O2, 32.5 ± 1°C) were investigated on the respiratory activity of rat liver homogenates and the activity of monoamine oxidase in isolated rat liver preparations. Exposure to a hyperbaric environment for 84 days caused selective in vitro inhibition of nicotinamide adenine dinucleotide (NAD) dependent oxidation of pyruvate, D isocitrate, and α ketoglutarate by rat liver homogenates. The addition of NAD to the reaction mixture decreased the degree of such an inhibition. No effects on the in vitro activity of liver monoamine oxidase and its inhibition by pheniprazine were observed during exposure of animals to a prolonged high pressure environment.

AB - The effects of a prolonged hyperbaric environment (21 ATA He O2, 200 ± 30 mm Hg O2, 32.5 ± 1°C) were investigated on the respiratory activity of rat liver homogenates and the activity of monoamine oxidase in isolated rat liver preparations. Exposure to a hyperbaric environment for 84 days caused selective in vitro inhibition of nicotinamide adenine dinucleotide (NAD) dependent oxidation of pyruvate, D isocitrate, and α ketoglutarate by rat liver homogenates. The addition of NAD to the reaction mixture decreased the degree of such an inhibition. No effects on the in vitro activity of liver monoamine oxidase and its inhibition by pheniprazine were observed during exposure of animals to a prolonged high pressure environment.

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Effects of a hyperbaric environment on respiratory and monoamine oxidase activities

Abstract

ASJC Scopus subject areas

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