Effects of bioactive marine-derived liposomes on two human breast cancer cell lines

Jie Li, Kamil Elkhoury, Claire Barbieux, Michel Linder, Stéphanie Grandemange, Ali Tamayol, Grégory Francius, Elmira Arab-Tehrany

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Breast cancer is the leading cause of death from cancer among women. Higher consumption of dietary marine n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) is associated with a lower risk of breast cancer. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two n-3 LC-PUFAs found in fish and exert anticancer effects. In this study, natural marine-derived lecithin that is rich in various polyunsaturated fatty acids (PUFAs) was extracted from salmon heads and transformed into nanoliposomes. These nanoliposomes were characterized and cultured with two breast cancer lines (MCF-7 and MDA-MB-231). The nanoliposomes decreased the proliferation and the stiffness of both cancer cell types. These results suggest that marine-derived lecithin possesses anticancer properties, which may have an impact on developing new liposomal delivery strategies for breast cancer treatment.

Original languageEnglish (US)
Article number211
JournalMarine Drugs
Volume18
Issue number4
DOIs
StatePublished - 2020

Keywords

  • Breast cancer
  • DHA
  • EPA
  • Liposomes
  • Omega-3
  • PUFA

ASJC Scopus subject areas

  • Drug Discovery

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    Li, J., Elkhoury, K., Barbieux, C., Linder, M., Grandemange, S., Tamayol, A., Francius, G., & Arab-Tehrany, E. (2020). Effects of bioactive marine-derived liposomes on two human breast cancer cell lines. Marine Drugs, 18(4), [211]. https://doi.org/10.3390/md18040211