Effects of center type and socioeconomic factors on early mortality and overall survival of diffuse large B-cell lymphoma

Prajwal Dhakal, Baojiang Chen, Smith Giri, Julie M. Vose, James O. Armitage, Vijaya Raj Bhatt

Research output: Contribution to journalArticle

Abstract

Aim: To examine whether the center type and socioeconomic factors significantly impact 1-month mortality and overall survival (OS) of patients with diffuse large B-cell lymphoma (DLBCL). Methods: National Cancer Database (NCDB) was used to identify patients diagnosed with diffuse large B-cell lymphoma from 2006 to 2012 (postrituximab era). Results: Among 185,183 patients, 33% were treated at academic centers. The receipt of therapy at larger volume centers was associated with improved 1-month mortality. Academic centers had better OS than nonacademic centers in univariable analysis. Younger age, private insurance, lower Charlson comorbidity score and lower lymphoma stage were associated with improved 1-month mortality and OS. Conclusion: The receipt of therapy at larger volume centers and socioeconomic factors were associated with improved survival.

Original languageEnglish (US)
Pages (from-to)2113-2124
Number of pages12
JournalFuture Oncology
Volume15
Issue number18
DOIs
StatePublished - Jun 2019

Keywords

  • academic center
  • cancer care
  • center volume
  • diffuse large B-cell lymphoma
  • disparity
  • mortality
  • socioeconomic factors
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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