Abstract
Abstract— The effects of chronic (14 day) administration of nicotine (1·5 mg kg−1 day−1) on the rat nucleus accumbens have been examined. Pretreatment of animals with nicotine increased the endogenous level of dopamine. The ability of (+)‐amphetamine to stimulate formation and release of [3H]dopamine from [3H]tyrosine was greatly potentiated in tissue slices from the nucleus accumbens of rats pretreated with nicotine. Furthermore, nicotine was effective in stimulating the formation and release of from [3H]dopamine from [3H]tyrosine in tissue slices from chronic nicotine‐treated animals. 1989 Royal Pharmaceutical Society of Great Britain
Original language | English (US) |
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Pages (from-to) | 66-68 |
Number of pages | 3 |
Journal | Journal of Pharmacy and Pharmacology |
Volume | 41 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1989 |
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science