Effects of Ciprofloxacin on the Humoral and Cellular Immune Responses in Balb/c-Mice

W. Roszkowski, H. L. Ko, K. Roszkowski, P. Ciborowski, J. Jeljaszewicz, G. Pulverer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effects of a 7 days chemotherapy with ciprofloxacin on the humoral and cellular immune responses in Balb/c-mice were examined. Ciprofloxacin-doses used were calculated on a body weight basis from therapeutic dosages in humans. In a dose-dependent way IgM as well as IgG responses were significantly increased. The delayed-type hypersensitivity reaction to oxazolone was not significantly changed. In in vivo as well in vitro experiments ciprofloxacin showed no modulatory activity on the concanavalin A and LPS-induced proliferative activities of mouse spleen cells.

Original languageEnglish (US)
Pages (from-to)396-402
Number of pages7
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume262
Issue number3
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology

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