Effects of crosstalks between sumoylation and phosphorylation in normal cellular physiology and human diseases

Q. Nie, X. D. Gong, M. Liu, D. W.C. Li

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Post-translational modifications (PTMs) such as phosphorylation, acetylation, methylation, ubiquitylation, sumoylation are important mechanisms to regulate functions of different proteins. Among various PTMs, phosphorylation, discovered about 60 years ago, is probably the most common modification. In contrast, sumoylation, identified about two decades ago is emerging as a key regulatory mechanism modulating protein functions. Although studies on protein phosphorylation and sumoylation have been extensively reviewed, much less attention has been paid to their cross-talk and their co-regulation of the same protein target. Here we summarize various examples of the cross-talks between protein phosphorylation and sumoylation, and discuss their functions in regulating normal physiology and pathogenesis.

Original languageEnglish (US)
Pages (from-to)906-913
Number of pages8
JournalCurrent Molecular Medicine
Volume16
Issue number10
DOIs
StatePublished - Dec 1 2016

Keywords

  • PTM
  • Phosphorylation
  • Protein functions
  • Sumoylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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