Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles

Z. Zhao, L. Yu-Long, H. Rui-Rong

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of endothelin on electrophysiological activity and contractility were examined in guinea pig papillary muscle using intracellular microelectrode and contractile tension recording technique. The results indicated that ET-1 prolonged APD, especially PPD and increased the contractile tension in a dose-dependent manner. The ET-induced effects were not influenced by K+ channel blocker TE(A), but inhibited by L-type Ca2+ channel blocker nifedipine, ET(A) receptor selective antagonist BQ-123 and atriopeptin III in a concentration-dependent manner. It is suggested that the changes in electrophysiological activity and the positive inotropic effect induced by ET-1 in guinea pig muscles are due to the elevation of intracellular calcium, which may be mediated by ETA receptor.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalActa Physiologica Sinica
Volume49
Issue number2
StatePublished - 1997
Externally publishedYes

Keywords

  • Atriopeptin III
  • BQ-123
  • Electrophysiology
  • Endothelin
  • Nifedipine
  • Papillary muscle
  • TEA

ASJC Scopus subject areas

  • Medicine(all)

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