Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles

Zhao Zhang; Yu Long Li; Rui Rong He

Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles

Zhao Zhang, Yu Long Li, Rui Rong He

Research output: Contribution to journal › Article › peer-review

Abstract

Effects of endothelin on electrophysiologica, activity and contractility were examined in guinea pig papillary muscle using intracellular microelectrode and contractile tension recording technique. The results indicated that ET-1 prolonged APD, especially PPD and increased the contractile tension in a dose-dependent manner. The ET-induced effects were not influenced by K⁺ channel blocker TE_A, but inhibited by L-type Ca²⁺ channel blokKer nifedipine, ET_A receptor selective antagonist BQ-123 and atriopeptin III in a concentration-dependent manner. It is suggested that the changes in electrophysiological activity and the positive inotropic effect induced by ET-1 in guinea pig muscles are due to the elevation of intracellular calcium, which may be melted by ET_A receptor.

Original language	English (US)
Pages (from-to)	146-152
Number of pages	7
Journal	Acta Physiologica Sinica
Volume	49
Issue number	2
State	Published - 1997
Externally published	Yes

Keywords

Atriopeptin III
BQ-123
Electrophysiology
Endothelin
Nifedipine
Papillary muscle
TEA

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles",

abstract = "Effects of endothelin on electrophysiologica, activity and contractility were examined in guinea pig papillary muscle using intracellular microelectrode and contractile tension recording technique. The results indicated that ET-1 prolonged APD, especially PPD and increased the contractile tension in a dose-dependent manner. The ET-induced effects were not influenced by K+ channel blocker TEA, but inhibited by L-type Ca2+ channel blokKer nifedipine, ETA receptor selective antagonist BQ-123 and atriopeptin III in a concentration-dependent manner. It is suggested that the changes in electrophysiological activity and the positive inotropic effect induced by ET-1 in guinea pig muscles are due to the elevation of intracellular calcium, which may be melted by ETA receptor.",

keywords = "Atriopeptin III, BQ-123, Electrophysiology, Endothelin, Nifedipine, Papillary muscle, TEA",

author = "Zhao Zhang and Li, {Yu Long} and He, {Rui Rong}",

year = "1997",

language = "English (US)",

volume = "49",

pages = "146--152",

journal = "Acta Physiologica Sinica",

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TY - JOUR

T1 - Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles

AU - Zhang, Zhao

AU - Li, Yu Long

AU - He, Rui Rong

PY - 1997

Y1 - 1997

N2 - Effects of endothelin on electrophysiologica, activity and contractility were examined in guinea pig papillary muscle using intracellular microelectrode and contractile tension recording technique. The results indicated that ET-1 prolonged APD, especially PPD and increased the contractile tension in a dose-dependent manner. The ET-induced effects were not influenced by K+ channel blocker TEA, but inhibited by L-type Ca2+ channel blokKer nifedipine, ETA receptor selective antagonist BQ-123 and atriopeptin III in a concentration-dependent manner. It is suggested that the changes in electrophysiological activity and the positive inotropic effect induced by ET-1 in guinea pig muscles are due to the elevation of intracellular calcium, which may be melted by ETA receptor.

AB - Effects of endothelin on electrophysiologica, activity and contractility were examined in guinea pig papillary muscle using intracellular microelectrode and contractile tension recording technique. The results indicated that ET-1 prolonged APD, especially PPD and increased the contractile tension in a dose-dependent manner. The ET-induced effects were not influenced by K+ channel blocker TEA, but inhibited by L-type Ca2+ channel blokKer nifedipine, ETA receptor selective antagonist BQ-123 and atriopeptin III in a concentration-dependent manner. It is suggested that the changes in electrophysiological activity and the positive inotropic effect induced by ET-1 in guinea pig muscles are due to the elevation of intracellular calcium, which may be melted by ETA receptor.

KW - Atriopeptin III

KW - BQ-123

KW - Electrophysiology

KW - Endothelin

KW - Nifedipine

KW - Papillary muscle

KW - TEA

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ER -

Effects of endothelin on electrophysiological and contractile activity of guinea pig papillary muscles

Abstract

Keywords

ASJC Scopus subject areas

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