Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection

Jennifer J. Kiser, Kenneth A. Lichtenstein, Peter L. Anderson, Courtney V. Fletcher

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The effects of proton pump inhibitors on the pharmacokinetics of atazanavir and amprenavir (administered as fosamprenavir) were rigorously evaluated in healthy volunteers in two studies, but formal studies in persons infected with human immunodeficiency virus (HIV) are lacking. We describe a 65-year-old man with HIV who underwent a 12-hour intensive pharmacokinetic study while receiving esomeprazole with atazanavir-ritonavir and subsequently, an 8-hour study while receiving esomeprazole with fosamprenavir-ritonavir. Consistent with the data in healthy volunteers, a major interaction between esomeprazole and atazanavir-ritonavir was observed in this patient-marked reductions in atazanavir trough plasma concentration and in the area under the concentration-time curve from 0-24 hours-whereas an interaction between esomeprazole and fosamprenavir-ritonavir was not apparent in this patient.

Original languageEnglish (US)
Pages (from-to)511-514
Number of pages4
JournalPharmacotherapy
Volume26
Issue number4
DOIs
StatePublished - Apr 2006

Keywords

  • Atazanavir
  • Esomeprazole
  • Fosamprenavir
  • HIV
  • Human immunodeficiency virus
  • Omeprazole
  • Pharmacokinetics
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Pharmacology (medical)

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