Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues

J. G. Sharp; D. B. Thomas; Cecilie V. Briscoe

doi:10.1159/000221275

Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues

J. G. Sharp, D. B. Thomas, Cecilie V. Briscoe

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

Original language	English (US)
Pages (from-to)	304-313
Number of pages	10
Journal	Chemotherapy
Volume	18
Issue number	5
DOIs	https://doi.org/10.1159/000221275
State	Published - 1973
Externally published	Yes

Keywords

Bone marrow regeneration
Granulocytopoiesis
Mouse bone marrow
Nitrogen mustard

ASJC Scopus subject areas

Oncology
Pharmacology
Drug Discovery
Pharmacology (medical)
Infectious Diseases

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title = "Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues",

abstract = "During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.",

keywords = "Bone marrow regeneration, Granulocytopoiesis, Mouse bone marrow, Nitrogen mustard",

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year = "1973",

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AU - Sharp, J. G.

AU - Thomas, D. B.

AU - Briscoe, Cecilie V.

PY - 1973

Y1 - 1973

N2 - During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

AB - During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

KW - Bone marrow regeneration

KW - Granulocytopoiesis

KW - Mouse bone marrow

KW - Nitrogen mustard

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JF - Chemotherapy

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ER -

Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues

Abstract

Keywords

ASJC Scopus subject areas

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