Effects of mustine hydrochloride on mouse haematopoietic and lymphoid tissues

J. G. Sharp, D. B. Thomas, Cecilie V. Briscoe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

During the first 4 days after the intravenous administration of a lethal dose (100 μg) of mustine hydrochloride to mice, there is a marked decrease in the weights of the lymph nodes, thymus and spleen and in the cellularity of the femoral bone marrow. In the subsequent 4 days, the cellularity of the bone marrow increases to values within the normal range while the weights of the lymph nodes, thymus and spleen remain exceedingly small. In this bone marrow regenerating after the injection of mustine hydrochloride, 94% of the recognisable haematopoietic cells are granulocytes at various stages of maturation.

Original languageEnglish (US)
Pages (from-to)304-313
Number of pages10
JournalChemotherapy
Volume18
Issue number5
DOIs
StatePublished - 1973

Keywords

  • Bone marrow regeneration
  • Granulocytopoiesis
  • Mouse bone marrow
  • Nitrogen mustard

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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