Abstract
The content of cytochrome P-450 and activities of aniline hydroxylase and glucose-6-phosphatase were determined in the livers of rats fed ethanol and nicotinic acid singly and in combination for 4 weeks. Similar determinations were conducted in livers from rats administered phenobarbital and nicotinic acid alone and in combination for 4 weeks. Both chronic ethanol feeding and phenobarbital administration increased the content of cytochrome P-450 and aniline hydroxylase activity. Glucose-6-phos-phatase activity was elevated by ethanol feeding but not by phenobarbital. Nicotinic acid treatment increased the content of cy-tochrome P-450 and aniline hydroxylation in the ethanol-treated but not in the control or phenobarbital-treated animals. Nicotinic acid did not influence the activity of glucose-6-phosphatase in either the ethanol- or phenobarbital-treated rats. The results of this study are consistent with the existence of a unique cytochrome P-450 which is induced by ethanol feeding, and the induction of this hemoprotein is further enhanced by the concomitant administration of nicotinic acid with ethanol.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 67-70 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 155 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1977 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology