Abstract
Peroxisome proliferator-activated receptor-γ (PPAR-γ) plays a critical role in glucose and lipid metabolism. More recently, PPAR-γ ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR-γ agonists have been demonstrated to have similar effects on microglia. PPAR-γ agonists also ameliorate experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This Mini-Review summarizes the effects of PPAR-γ agonists in mediating immune responses and the potential of these agonists in the treatment of inflammatory disorders of the CNS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-325 |
| Number of pages | 11 |
| Journal | Journal of Neuroscience Research |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2003 |
| Externally published | Yes |
Keywords
- 15d-PGJ
- Brain abscess
- EAE
- Microglia
- PPAR-γ
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience