Effects of peroxisome proliferator-activated receptor-γ agonists on central nervous system inflammation

Tammy Kielian, Paul D. Drew

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations

Abstract

Peroxisome proliferator-activated receptor-γ (PPAR-γ) plays a critical role in glucose and lipid metabolism. More recently, PPAR-γ ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR-γ agonists have been demonstrated to have similar effects on microglia. PPAR-γ agonists also ameliorate experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This Mini-Review summarizes the effects of PPAR-γ agonists in mediating immune responses and the potential of these agonists in the treatment of inflammatory disorders of the CNS.

Original languageEnglish (US)
Pages (from-to)315-325
Number of pages11
JournalJournal of Neuroscience Research
Volume71
Issue number3
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

Keywords

  • 15d-PGJ
  • Brain abscess
  • EAE
  • Microglia
  • PPAR-γ

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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