Effects of physiologic human brain motion on proton spectroscopy: Quantitative analysis and correction with cardiac gating

Pradip M. Pattany, Imad H. Khamis, Brian C. Bowen, Karl Goodkin, R. Gregory Weaver, James B. Murdoch, M. Judith Donovon Post, Robert M. Quencer

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Proton MR spectroscopy is a powerful noninvasive method that enables measurement of certain brain metabolites in healthy subjects and patients with diseases. A major difficulty with clinical and research applications of in vivo proton MR spectroscopy is the variability of metabolite concentrations, especially in regions with substantial physiologic motion. In our preliminary evaluation, we tested the hypothesis that physiologic brain motion leads to lower mean metabolite concentrations and higher SDs for the measured metabolite concentrations.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume23
Issue number2
StatePublished - 2002

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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