Effects of postnatal dexamethasone exposure on the developmental outcome of premature infants

Howard Needelman, Martha Evans, Holly Roberts, Matthew Sweney, J. B. Bodensteiner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Extremely low birth weight premature infants are at risk for poor neurodevelopmental outcome. Postnatal dexamethasone has often been used in premature infants to prevent or treat bronchopulmonary dysplasia, and this drug is thought by some to affect neurodevelopmental outcome. We retrospectively examined the effect of this steroid on early neurodevelopment. Dexamethasone exposure was associated with an adverse outcome and was a stronger predictor of outcome than other accepted risk factors. If used, dexamethasone should be used in these high-risk infants for as short a period as possible.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalJournal of Child Neurology
Volume23
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Developmental outcome
  • Dexamethasone
  • Premature infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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