Effects of reduced food intake on morphometry and cell production in the small intestine of the rat

H. L. Lipscomb, J. G. Sharp

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Abstract

The present study examined the effects of a 60% reduction in food intake on kinetic and morphometric parameters in the small intestine of adult male Lewis rats. We observed that, after 20 days, the wet weight of jejunum and ileum, thickness of muscularis externa of duodenum, crypt depth throughout the intestine, and DPM/mg and DPM/crypt in ileum were decreased in animals on reduced food intake when compared to their paired, normally fed controls. These results demonstrated that reduced food intake caused distinctive effects focused primarily in the ileum, thus opening to question the use of the technique of pair feeding as a control for studies of intestinal cell proliferation in which manipulations of the animals result in altered food intake or body weight.

Original languageEnglish (US)
Title of host publicationVirchows Archiv Abteilung B Cell Pathology
Pages285-292
Number of pages8
Volume41
Edition3
StatePublished - 1982

ASJC Scopus subject areas

  • Medicine(all)

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    Lipscomb, H. L., & Sharp, J. G. (1982). Effects of reduced food intake on morphometry and cell production in the small intestine of the rat. In Virchows Archiv Abteilung B Cell Pathology (3 ed., Vol. 41, pp. 285-292)