Effects of subdural application of lidocaine in patients with focal epilepsy

Deepak Madhavan; Piotr Mirowski; Nandor Ludvig; Chad Carlson; Werner Doyle; Orrin Devinsky; Ruben Kuzniecky

doi:10.1016/j.eplepsyres.2007.11.007

Effects of subdural application of lidocaine in patients with focal epilepsy

Deepak Madhavan, Piotr Mirowski, Nandor Ludvig, Chad Carlson, Werner Doyle, Orrin Devinsky, Ruben Kuzniecky

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.

Original language	English (US)
Pages (from-to)	235-239
Number of pages	5
Journal	Epilepsy Research
Volume	78
Issue number	2-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2007.11.007
State	Published - Feb 2008
Externally published	Yes

Keywords

Epilepsy
Focal
Lidocaine
Transmeningeal

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.eplepsyres.2007.11.007

Cite this

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abstract = "Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.",

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AU - Mirowski, Piotr

AU - Ludvig, Nandor

AU - Carlson, Chad

AU - Doyle, Werner

AU - Devinsky, Orrin

AU - Kuzniecky, Ruben

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AB - Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.

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Effects of subdural application of lidocaine in patients with focal epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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