Effects of subdural application of lidocaine in patients with focal epilepsy

Deepak Madhavan, Piotr Mirowski, Nandor Ludvig, Chad Carlson, Werner Doyle, Orrin Devinsky, Ruben Kuzniecky

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients. Administration of lidocaine resulted in a marked diminishment of spike counts on all patients, with a decremental effect of lidocaine on the faster frequency elements of individual spikes and overall testing epochs. The direct cortical application of lidocaine appears to affect local epileptogenic activity in human patients with intractable focal epilepsy.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalEpilepsy Research
Volume78
Issue number2-3
DOIs
StatePublished - Feb 2008

Keywords

  • Epilepsy
  • Focal
  • Lidocaine
  • Transmeningeal

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Madhavan, D., Mirowski, P., Ludvig, N., Carlson, C., Doyle, W., Devinsky, O., & Kuzniecky, R. (2008). Effects of subdural application of lidocaine in patients with focal epilepsy. Epilepsy Research, 78(2-3), 235-239. https://doi.org/10.1016/j.eplepsyres.2007.11.007