Effects of the anti-migraine drug sumatriptan on muscle energy metabolism: Relationship to side-effects

M. D. Boska, K. M.A. Welch, L. Schultz, J. Nelson

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Sumatriptan succinate (Imitrex) is a 5-HT(5-hydroxytryptamine) agonist used for relief of migraine symptoms. Some individuals experience short-lived side-effects, including heaviness of the limbs, chest heaviness and muscle aches and pains. The effects of this drug on skeletal muscle energy metabolism were studied during short submaximal isometric exercises. We studied ATP flux from anaerobic glycolysis (An Gly), the creatine kinase reaction (CK) and oxidative phosphorylation (Ox Phos) using 31P nuclear magnetic resonance spectroscopy (31P MRS) kinetic data collected during exercise. It was found that side-effects induced acutely by injection of 6 mg sumatriptan succinate s.c. were associated with reduced oxygen storage in peripheral skeletal muscle 5-20 min after injection as demonstrated by a transient reduction in mitochondrial function at end-exercise. These results suggest that mild vasoconstriction in peripheral skeletal muscle is associated with the action of sumatriptan and is likely to be the source of the side-effects experienced by some users. Migraine with aura patients were more susceptible to this effect than migraine without aura patients.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalCephalalgia
Volume20
Issue number1
DOIs
StatePublished - Dec 1 2000
Externally publishedYes

Keywords

  • Energy metabolism
  • Exercise
  • P MRS
  • Sumatriptan succinate

ASJC Scopus subject areas

  • Clinical Neurology

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