Effects of topical epinephrine on aqueous humor dynamics in the cat

Yun Liang Wang, Carol B. Toris, Guilin Zhan, Michael E. Yablonski

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The purpose of this study was to investigate, in cats, the effects of topical epinephrine on aqueous humor dynamics as measured by the non-invasive method of fluorophotometry and by other methods. Measurements were carried out on 12 cats before and after one week of twice daily treatment with 2 % epinephrine hydrochloride to one eye. Aqueous flow and outflow facility were determined using fluorophotometry. Uveoscleral outflow was calculated from these results and was evaluated with anterior chamber perfusion of FITC- dextran. Outflow facility also was measured by tonography. Epinephrine- treated eyes, compared with their baseline values, showed a 31 % reduction in intraocular pressure (P < 0.001), a 23 % reduction in aqueous flow (P < 0.05), a 60 % increase in fluorophotometric outflow facility (P < 0.05), and a 43 % increase in tonographic outflow facility (P < 0.05). Treated eyes, compared with contralateral control eyes, showed a 27 % reduction in IOP (P < 0.005), a 25 % reduction in aqueous flow (P < 0.005), a 38 % increase in fluorophotometric outflow facility (P < 0.05), and a 34 % increase in tonographic outflow facility. When evaluated by both fluorophotometry and FITC-dextran tracer methods, epinephrine had no significant effect on uveoscleral outflow. It was concluded that, in cats treated with topical epinephrine twice daily for a week, a reduction in intraocular pressure is induced by an increase in outflow facility and decrease in aqueous flow.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalExperimental Eye Research
Volume68
Issue number4
DOIs
StatePublished - Apr 1999

Keywords

  • Aqueous flow
  • Cat
  • Epinephrine
  • Fluorophotometry
  • Intraocular pressure
  • Outflow facility
  • Uveoscleral outflow

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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