Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate

William H. Roccaforte; Charles R. Wesley; Joseph P. Gilmore

doi:10.1159/000172953

Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate

William H. Roccaforte, Charles R. Wesley, Joseph P. Gilmore

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The renal responses to an intravenous infusion of a high O₂ affinity fluorocarbon equal to 15% of the estimated blood volume was determined in 5 monkeys and 1 baboon. In response to the infusion, blood pressure, renal plasma flow and glomerular filtration rate did not change significantly while heart rate and central venous pressure increased transiently. Significant increases in sodium and potassium excretion and osmolal and free-water clearances occurred. The renal responses to Fluosol-DA (20%) mimic in general those observed when blood volume is expanded with isotonic isooncotic dextran solutions.

Original language	English (US)
Pages (from-to)	293-298
Number of pages	6
Journal	Kidney and Blood Pressure Research
Volume	7
Issue number	5
DOIs	https://doi.org/10.1159/000172953
State	Published - 1984
Externally published	Yes

Keywords

Fluorocarbons
Renal function
Volume expansion

ASJC Scopus subject areas

Nephrology
Cardiology and Cardiovascular Medicine

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10.1159/000172953

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title = "Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate",

abstract = "The renal responses to an intravenous infusion of a high O2 affinity fluorocarbon equal to 15% of the estimated blood volume was determined in 5 monkeys and 1 baboon. In response to the infusion, blood pressure, renal plasma flow and glomerular filtration rate did not change significantly while heart rate and central venous pressure increased transiently. Significant increases in sodium and potassium excretion and osmolal and free-water clearances occurred. The renal responses to Fluosol-DA (20%) mimic in general those observed when blood volume is expanded with isotonic isooncotic dextran solutions.",

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AU - Wesley, Charles R.

AU - Gilmore, Joseph P.

PY - 1984

Y1 - 1984

N2 - The renal responses to an intravenous infusion of a high O2 affinity fluorocarbon equal to 15% of the estimated blood volume was determined in 5 monkeys and 1 baboon. In response to the infusion, blood pressure, renal plasma flow and glomerular filtration rate did not change significantly while heart rate and central venous pressure increased transiently. Significant increases in sodium and potassium excretion and osmolal and free-water clearances occurred. The renal responses to Fluosol-DA (20%) mimic in general those observed when blood volume is expanded with isotonic isooncotic dextran solutions.

AB - The renal responses to an intravenous infusion of a high O2 affinity fluorocarbon equal to 15% of the estimated blood volume was determined in 5 monkeys and 1 baboon. In response to the infusion, blood pressure, renal plasma flow and glomerular filtration rate did not change significantly while heart rate and central venous pressure increased transiently. Significant increases in sodium and potassium excretion and osmolal and free-water clearances occurred. The renal responses to Fluosol-DA (20%) mimic in general those observed when blood volume is expanded with isotonic isooncotic dextran solutions.

KW - Fluorocarbons

KW - Renal function

KW - Volume expansion

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Effects of volume expansion with fluosol-DA on renal function of the nonhuman primate

Abstract

Keywords

ASJC Scopus subject areas

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