TY - JOUR
T1 - Efferent feedback controls bilateral auditory spontaneous activity
AU - Wang, Yixiang
AU - Sanghvi, Maya
AU - Gribizis, Alexandra
AU - Zhang, Yueyi
AU - Song, Lei
AU - Morley, Barbara
AU - Barson, Daniel G.
AU - Santos-Sacchi, Joseph
AU - Navaratnam, Dhasakumar
AU - Crair, Michael
N1 - Funding Information:
We would like to thank Dr. Dwight Bergles and the Bergles lab at Johns Hopkins University, all members of the Crair lab, the Santos-Sacchi lab, and the Navaratnam lab for their helpful comments on this project. We would like to thank Dr. Leonard Kaczmarek and Dr. Yalan Zhang for providing apamin for pilot pharmacological experiments. We would like to thank Dr. Winston Tan and Dr. Jun-ping Bai for providing guidance on conducting ABR experiments. We would like to thank Dr. Steven W. Zucker and for suggestions on applying diffusion map analysis. We would like to thank Dr. Rui Chang and Chuyue Yu for providing Alexa Fluor® 647 AffiniPure Donkey Anti-Goat IgG (H + L) antibody. We would like to thank Dr. Matthew McGinley for setting up the “Baphy” software. We would like to thank Dr. Jessica Cardin for helpful discussions regarding this study, and the family of William Ziegler III for their support. This work was supported by NIDCD R01DC008860.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - In the developing auditory system, spontaneous activity generated in the cochleae propagates into the central nervous system to promote circuit formation. The effects of peripheral firing patterns on spontaneous activity in the central auditory system are not well understood. Here, we describe wide-spread bilateral coupling of spontaneous activity that coincides with the period of transient efferent modulation of inner hair cells from the brainstem medial olivocochlear system. Knocking out α9/α10 nicotinic acetylcholine receptors, a requisite part of the efferent pathway, profoundly reduces bilateral correlations. Pharmacological and chemogenetic experiments confirm that the efferent system is necessary for normal bilateral coupling. Moreover, auditory sensitivity at hearing onset is reduced in the absence of pre-hearing efferent modulation. Together, these results demonstrate how afferent and efferent pathways collectively shape spontaneous activity patterns and reveal the important role of efferents in coordinating bilateral spontaneous activity and the emergence of functional responses during the prehearing period.
AB - In the developing auditory system, spontaneous activity generated in the cochleae propagates into the central nervous system to promote circuit formation. The effects of peripheral firing patterns on spontaneous activity in the central auditory system are not well understood. Here, we describe wide-spread bilateral coupling of spontaneous activity that coincides with the period of transient efferent modulation of inner hair cells from the brainstem medial olivocochlear system. Knocking out α9/α10 nicotinic acetylcholine receptors, a requisite part of the efferent pathway, profoundly reduces bilateral correlations. Pharmacological and chemogenetic experiments confirm that the efferent system is necessary for normal bilateral coupling. Moreover, auditory sensitivity at hearing onset is reduced in the absence of pre-hearing efferent modulation. Together, these results demonstrate how afferent and efferent pathways collectively shape spontaneous activity patterns and reveal the important role of efferents in coordinating bilateral spontaneous activity and the emergence of functional responses during the prehearing period.
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U2 - 10.1038/s41467-021-22796-8
DO - 10.1038/s41467-021-22796-8
M3 - Article
C2 - 33907194
AN - SCOPUS:85105101314
SN - 2041-1723
VL - 12
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2449
ER -