Efficacy and Freedom: Patient Experiences with the Transition from Daily Oral to Long-Acting Injectable Antiretroviral Therapy to Treat HIV in the Context of Phase 3 Trials

Andrea Mantsios, Miranda Murray, Tahilin S. Karver, Wendy Davis, David Margolis, Princy Kumar, Susan Swindells, U. Fritz Bredeek, Miguel García del Toro, Mercedes Garcia Gasalla, Rafael Rubio García, Antonio Antela, Krischan Hudson, Sandy Griffith, Deanna Kerrigan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Using in-depth interviews, this study sought to understand the experiences of PLHIV (n = 53) participating in Phase 3 LA ART trials in the United States and Spain. The most salient consideration when contemplating LA ART was its clinical efficacy; many participants reported wanting to ensure that it worked as well as daily oral ART, including with less frequent dosing (every 8 versus 4 weeks). While injection side effects were often reported, most participants felt that regimen benefits outweighed such drawbacks. Participants described the main benefit of LA ART as the “freedom” it afforded both logistically and psychosocially, including through reduced HIV stigma. Findings highlight the importance of patient-provider communication related to weighing potential benefits and side effects and the continued need to address HIV stigma.

Original languageEnglish (US)
Pages (from-to)3473-3481
Number of pages9
JournalAIDS and Behavior
Volume24
Issue number12
DOIs
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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