Efficient synthesis of tricyclic benzobisoxazines by silica gel catalysis

Gaëlle Spagnol, Andrzej Rajca, Suchada Rajca

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


A new method for the synthesis of tricyclic benzobisoxazines, based upon silica gel-catalyzed formation of two 3,1-oxazine rings, is reported. The reversibility of the condensation reaction, forming an oxazine ring, allows for implementation of silica gel catalyzed ketone exchange in benzobisoxazine, thus enabling access to nonsymmetric derivatives of benzobisoxazines.

Original languageEnglish (US)
Pages (from-to)1867-1869
Number of pages3
JournalJournal of Organic Chemistry
Issue number5
StatePublished - Mar 2 2007

ASJC Scopus subject areas

  • Organic Chemistry


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