EHD proteins: Key conductors of endocytic transport

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations

Abstract

Regulation of endocytic transport is controlled by an elaborate network of proteins. Rab GTP-binding proteins and their effectors have well-defined roles in mediating specific endocytic transport steps, but until recently less was known about the four mammalian dynamin-like C-terminal Eps15 homology domain (EHD) proteins that also regulate endocytic events. In recent years, however, great strides have been made in understanding the structure and function of these unique proteins. Indeed, a growing body of literature addresses EHD protein structure, interactions with binding partners, functions in mammalian cells, and the generation of various new model systems. Accordingly, this is now an opportune time to pause and review the function and mechanisms of action of EHD proteins, and to highlight some of the challenges and future directions for the field.

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalTrends in Cell Biology
Volume21
Issue number2
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Cell Biology

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