Elastic sealants for surgical applications

Nasim Annabi, Kan Yue, Ali Tamayol, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.

Original languageEnglish (US)
Pages (from-to)27-39
Number of pages13
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
StatePublished - Sep 1 2015
Externally publishedYes


  • Adhesion
  • Elasticity
  • Hydrogel
  • Surgical applications
  • Surgical sealants
  • Tissue adhesives

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science


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